일송생명과학연구소

Lab of Prion Diseases and Neurotropic Viruses Research

Yong-Sun Kim, M.D., Ph.D.

Research Interests

1. The pathogenic mechanisms of neurodegeneration in Prion diseases 

2. Diagnosis of human Prion diseases

3. The study on role of endogenous retroviruses in aging and neurodegenerative disorders

Publications

1. Kim S, Kim YS, Park KD, Lee SA. Creutzfeldt-Jakob Disease With Double Mutations at Codon 180 and Codon 232 of PRNP. J Clin Neurol. 2025 Jan;21(1):74-76. doi: 10.3988/jcn.2024.0431.

2. Jin HT, Kim YS, Choi EK. Human papillomavirus and Merkel cell polyomavirus in Korean patients with nonsmall cell lung cancer: Evaluation and genetic variability of the noncoding control region. J Med Virol. 2024 Aug;96(8):e29880. doi: 10.1002/jmv.29880.

3. Kim D, Kim M, Kim J, Baek K, Park H, Park S, Kang BM, Kim S, Kim MJ, Mostafa MN, Maharjan S, Shin HE, Lee MH, Il Kim J, Park MS, Kim YS, Choi EK, Lee Y, Kwon HJ. A mouse xenograft long-term replication yields a SARS-CoV-2 Delta mutant with increased lethality. J Med Virol. 2024 Feb;96(2):e29459. doi: 10.1002/jmv.29459.

4. Choi YG, Jang B, Park JH, Choi MW, Lee GY, Cho DJ, Kim HY, Lim HK, Lee WJ, Choi EK, Kim YS. Radotinib Decreases Prion Propagation and Prolongs Survival Times in Models of Prion Disease. Int J Mol Sci. 2023 Jul 31;24(15):12241. doi: 10.3390/ijms241512241.

5. Kim DH, Kim J, Lee H, Lee D, Im SM, Kim YE, Yoo M, Cheon YP, Bartz JC, Son YJ, Choi EK, Kim YS, Jeon JH, Kim HS, Lee S, Ryou C, Nam TG. Synthesis and anti-prion aggregation activity of acylthiosemicarbazide analogues. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2191164. doi: 10.1080/14756366.2023.2191164.

6. Kim MJ, Kim HJ, Jang B, Kim HJ, Mostafa MN, Park SJ, Kim YS, Choi EK. Impairment of Neuronal Mitochondrial Quality Control in Prion-Induced Neurodegeneration. Cells. 2022 Sep 2;11(17):2744. doi: 10.3390/cells11172744.

7. Kim MJ, Cho YA, Kim E, Choe JY, Park JW, Lee J, Lee JW, Moon SH, Kim YS, Kim SE, Choi EK.Cellular Prion Protein Is Closely Associated with Early Recurrence and Poor Survival in Patients with Hepatocellular Carcinoma. Diagnostics (Basel). 2022 Jul 5;12(7):1635. doi: 10.3390/diagnostics12071635.

8. Lee YB, Min JK, Kim JG, Cap KC, Islam R, Hossain AJ, Dogsom O, Hamza A, Mahmud S, Choi DR, Kim YS, Koh YH, Kim HA, Chung WS, Suh SW, Park JB.Multiple functions of pyruvate kinase M2 in various cell types. J Cell Physiol. 2022 Jan;237(1):128-148. doi: 10.1002/jcp.30536. Epub 2021 Jul 26.

9. Cha S, Sin MJ, Kim MJ, Kim HJ, Kim YS, Choi EK, Kim MY. Involvement of Cellular Prion Protein in Invasion and Metastasis of Lung Cancer by Inducing Treg Cell Development. Biomolecules. 2021 Feb 15;11(2):285. doi: 10.3390/biom11020285.

10. Jang B, Kim MJ, Lee YJ, Ishigami A, Kim YS, Choi EK. Vimentin citrullination probed by a novel monoclonal antibody serves as a specific indicator for reactive astrocytes in neurodegeneration. Neuropathol Appl Neurobiol. 2020 Dec;46(7):751-769. doi: 10.1111/nan.12620.

11. Jin HT, Park SJ, Choi EK, Kim YS. The frequency of Merkel cell polyomavirus in whole blood from immunocompetent and immunosuppressed patients with kidney disease and healthy donors. Microb Pathog. 2019 Jun;131:75-80. doi: 10.1016/j.micpath.2019.03.020.

12. Park JH, Choi YG, Park SJ, Choi HS, Choi EK, Kim YS. Ultra-efficient Amplification of Abnormal Prion Protein by Modified Protein Misfolding Cyclic Amplification with Electric Current. Mol Neurobiol. 2018 Feb;55(2):1630-1638. doi: 10.1007/s12035-017-0431-8.

13. Wang F, Wang X, Orrú CD, Groveman BR, Surewicz K, Abskharon R, Imamura M, Yokoyama T, Kim YS, Vander Stel KJ, Sinniah K, Priola SA, Surewicz WK, Caughey B, Ma J. Self-propagating, protease-resistant, recombinant prion protein conformers with or without in vivo pathogenicity. PLoS Pathog. 2017 Jul 12;13(7):e1006491. doi: 10.1371/journal.ppat.1006491.